Tiềm năng ức chế sự lây truyền vi-rút SARS-CoV-2 qua đường miệng của keo ong
Các tác giả
Từ khóa:
keo ong, SARS-CoV, COVID-19, ACE2, xoang miệngTóm tắt
Thế giới đang nỗ lực nghiên cứu và phát triển các biện pháp để đối phó với đại dịch toàn cầu nghiêm trọng COVID-19 do vi-rút Corona SARS-CoV-2 gây ra. Mặc dù phần lớn sự chú ý đang tập trung vào trục lây nhiễm mũi - phổi, SARS-CoV-2 cũng có thể lây truyền qua xoang miệng. Men chuyển angiotensin 2 (ACE2) hiện diện trong tế bào và mô miệng có thể là cửa ngõ xâm nhập của SARS-CoV-2. Keo ong (hỗn hợp nhựa tự nhiên do ong mật sản xuất) có thể ức chế sự liên kết giữa ACE2 với vi-rút. Keo ong còn cho thấy tác động có lợi ở bệnh nhân COVID-19. Do đó, sử dụng keo ong để phòng ngừa lây nhiễm qua xoang miệng có thể là một biện pháp bổ sung giúp ngăn chặn sự lây truyền SARS-CoV-2 và góp phần chống lại đại dịch COVID-19.
Abstract
We are facing a serious global pandemic called the Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 virus. In the great effort to get back to the normalcy, any approach that may help to reduce the disease acquisition and progression is of interest. While most of the attention has concentrated on the nasal-lung axis of infection, literature indicates that SARS-CoV-2 transmission can occur through the oral cavity. Increasing evidences have demonstrated that angiotensin-converting-enzyme-2 (ACE2) is an entry factor of SARS-CoV-2 in the oral cells and tissues. Propolis, a natural resinous mixture produced by honey bees, has shown inhibitory effects on the binding between ACE2 and SARS-CoV-2. The administration of propolis may be beneficial for hospitalized adult COVID-19 patients in decreasing its impact. The use of propolis for oral infection should be considered as an additional mean of lowering virus transmission and enhancing the immune system to against the COVID-19 pandemic.
Tài liệu tham khảo
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